الفهرس 
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Abstract
SUMMARY
Male oligospermia affects 10% to 15% of males of reproductive age. Throughout the germ cell maturation process, male fertility necessitates the integration, communication, and functioning of several cell types in the testis.
Bisphenol A (BPA) is an industrial compound that is found in plastics. The principal route of human exposure is thought to be dietary consumption of packed food ingredients. Animal research has demonstrated that BPA exposure may impair male reproductive organs; however, human investigations on BPA exposure and male fertility have yielded equivocal findings.
Certain miRNAs play a crucial role in male oligospermia; abnormal miRNA expression influences sperm production at several stages and in diverse cell types, commonly resulting in oligospermia.
The purpose of this study was to look at the links between Bisphenol A exposure and sperm production-related miRNA337.
A Case-Control research on 73 individuals was done from February 2022 to June 2022 at the Andrology, Sexology, and STIs outpatient clinic at Beni-Suef University Hospital. (1) Group: 38 Oligospermia instances. This research included participants with non-obstructive azoospermia (n = 16), oligozoospermia (n = 22), and group (2): control normospermic (n = 35). All participants were given a thorough medical history, a physical examination, sperm analysis, and urine and blood samples. Urinary Bisphenol A and serum miRNA 337 levels were determined. We employed Pearson’s correlation coefficients to assess the specific chemical connections of Bisphenol A with sperm production-related miRNA337.
The mean miRNA 337 level in the oligozoospermia and azoospermia groups is significantly higher than in the fertile control group. The mean Bisphenol A level in the azoospermia group is statistically higher than in the fertile control group. The mean MDA level in the oligospermia group is significantly higher than in the fertile control group. There were no linear connections seen between BPA levels and sperm quality measures, hormonal profile, or miRNA 337.
In conclusion, the mean urine BPA and serum miRNA 337 levels in the oligospermia group rose as compared to the fertile control group, which may be mediated by oxidative stress as demonstrated by the MDA marker.