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العنوان
Introduction of Built-in Green Chemistry Principles in Design of Pharmaceutical Analytical Methods /
المؤلف
Megahed, Safa Mohamed Mohamed.
هيئة الاعداد
باحث / صفا محمد محمد مجاهد
مشرف / احمد عبدالمنعم حبيب
مناقش / شيؤين فاروق حماد
مناقش / اميره حسن كمال
الموضوع
Pharmaceutical Analytical Chemistry.
تاريخ النشر
2023.
عدد الصفحات
312 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
العلوم الصيدلية
تاريخ الإجازة
20/9/2023
مكان الإجازة
جامعة طنطا - كلية الصيدلة - Pharmaceutical Analytical Chemistry
الفهرس
Only 14 pages are availabe for public view

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from 368

Abstract

This thesis presents incorporation of Quality by Design principles in development of new green analytical methods for determination of some drugs either in bulk form, in their dosage forms, and/or in biological fluids. The drugs selected for this study are: favipiravir, benoxinate HCl-fluorescein sodium combination, amlodipine -atorvastatin combination, ciprofloxacin HCl-metronidazole combination, and spiramycin-metronidazole combination. The thesis consists of six parts: Part I This part includes a general introduction about Green Analytical Chemistry principles, techniques, and greenness assessment tools. Then, it discusses Quality by Design framework including risk assessment, experimental designs, and design space development. Finally, it presents different analytical methods that involve combined implementation of Quality by Design and green chemistry principles. Part II This part deals with the development and validation of green analytical methods for determination of anti COVID-19 drug; favipiravir in pure form, dosage form, and biological fluid.