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Abstract
Nephrotic syndrome constitutes a common clinical renal problem among children with chronic kidney diseases. Minimal change nephritic syndrome constitutes a higher incidence in patients with nephritic syndrome minimal change nephrotic syndrome show different pattern than that of the other pathological types regarding age, sex renal function, complications, progress to end nephrotic stage renal failure and treatment options. Complications of syndrome are numerous including hypovolemic shock, infections and thrombosis which is related to dyslipidemia and coagulopathy due to disturbed coagulation profiles. Recently the literature have focused on the role of plasminogen activator inhibitor and its gene encoding polymorphism as one of the factors that may contribute to thrombosis among nephrotic children