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Abstract
The enhancement of per-oral bioavailability of poorly water- soluble drugs remains one of the most challenging aspects of drug development, although salt formation, solubilization and particle size reduction have commonly been used to increase the dissolution rate and thereby per-oral absorption and bioavailability of such drugs. Preparation of solid dispersions using water soluble carriers is yet another popular approach used to improve per-oral bioavailability of poorly water soluble drugs. Solid dispersion techniques have attracted considerable interest of improving the dissolution rate of highly lipophilic drugs thereby improving their bioavailability by reducing drug particle size, improving wettability and forming amorphous particles. Formulation of such solid amorphous dispersions into immediate release solid dosage forms for oral administration to environment such as human gastro intestinal tract, it is often desirable to maximize the dose of the drug loaded, thereby minimize the dosage form’s size. It is easier for the patient to swallow this dosage form and thus tending to improve patient compliance