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Abstract
The ”double crush” or ”double pathology” hyopthesis, a term originally coined for increased susceptibility of nerves with proximal and distal compressive lesions. The metabolic stress of diabetes is the first crush, and compression of the nerve at the potential site of entrapment will cause the second crush. According to this hypothesis, most patients remain asymptomatic despite having diabetic nerve disease. Only when the second pathology occurs (compression of the nerves at entrapment sites) will the patients become symptomatic. Thus, it has been hypothesized that symptoms in diabetic sensorimotor neuropathy may be due, in part, to compression of multiple peripheral nerves