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Abstract
Fundus autofluorescence (FAF) is a noninvasive, rapid and potentially useful imaging modality that continues to evolve. It reflects metabolic changes in the RPE and thus provides an assay of retinal and RPE function. Lipofuscin accumulation is actually a hallmark of normal aging in many cells, including the RPE. Fundus autofluorescence monitors RPE lipofuscin in vivo. That is why FAF imaging appears to have an important role in the diagnosis of retinal dystrophies and their clinical variants and an increasing role in monitoring disease progression in patients with atrophic AMD. It is also used as a supplementary diagnostic tool for identifying patients with CSR and differentiating between acute and chronic cases and also in pre- and postoperative follow up of macular hole patients