![]() | Only 14 pages are availabe for public view |
Abstract Carbapenems are a class of Beta-lactam antibiotics with broad spectrum of antibacterial activity. They are often considered as a last resort in treatment of infections caused by multidrug-resistant organisms. Carbapenemase-producing Enterobacteriaceae (CPE) have been reported worldwide.Resistance to carbapenems in Enterobacteriaceae is caused mainly by carbapenemase production or by porin loss combined with the expression of Ý-lactamases like an extended-spectrum Beta-lactamase (ESBL) or AmpC. Klebsiella pneumoniae carbapenemase (KPC) class A (serine carbapenemases is one of the most prevalent carbapenemases in Enterobacteriaceae |