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العنوان
Synthesis, docking studies and pharmacological activity of novel quinoxaline derivatives /
الناشر
Sarah Hammad Mohamed Khairat ,
المؤلف
Sarah Hammad Mohamed Khairat
هيئة الاعداد
باحث / Sarah Hammad Mohamed Khairat
مشرف / Fatma Abdelfattah Ragab
مشرف / Hoda Ibrahim Eldiwani
مناقش / Sarah Hammad Mohamed Khairat
تاريخ النشر
2014
عدد الصفحات
137 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الصيدلة ، علم السموم والصيدلانيات (المتنوعة)
تاريخ الإجازة
31/3/2015
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - pharmaceutical Chemistry
الفهرس
Only 14 pages are availabe for public view

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Abstract

In the present investigation, synthesis, in vitro cytotoxic activity, Tyrosine kinase inhibition, COX-2 inhibition, docking and QSAR study of certain new quinoxaline derivatives were performed. The thesis consists of the following parts: 1. Introduction This part displayed a concise review describing the various pharmacological activity of quinoxaline derivatives including antitumor activity and various methods used for the synthesis of 3-hydrazinylquinoxalin-2(1H)- one. 2. Aim of the Present Investigation This part presented the pharmacological bases upon which the new synthesized compounds were designed