الفهرس 
Chemical and biological studies on the essential oil of some species of Lamiaceae
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Abstract
Natural sources, whether they are plants, marine organisms or microorganisms,
remain an essential source of exploration for natural chemical entities that can be
used in drug discovery to treat many health problems. Among the most important
current health problems are cancer diseases, inflammation, microbial infections and
health problems related to oxidation. from this point of view, the essential oils of
some species belonging to Lamiaceae family were used in this study. Major
components analysis of six Lavandula species showed significant variation between
species in the quality and quantity of EO composition. All studied lavandula
species/varieties appeared to be richest in oxygenated monoterpenes. Lavandula
angustifolia, Lavandula hybrida, Hyssopus officinalis and Perilla frutescens were
subjected for GC-MS analyses and several biological activities. Analyses by
GC/MS of the main constituents showed camphor as the main component in L.
angustifolia followed by eucalyptol and endo-borneol, β-cymene, α-pinene and βpinene. L. hybrida essential oil contained eucalyptol as the major component
followed by camphor, α-pinene and β-pinene. The major components of H.
officinalis essential oil were isopinocamphone that reached, followed by
pinochamphone, β-pinene, β-phellandrene, α-thujene and Bicyclo-germacrene. The
main constituents of the essential oil of P. frutescens constituent were identified as
L-perillaldehyde followed by trans-caryophyllene and D-limonene. In vitro study,
anti-inflammatory, anticancer, antioxidant and antimicrobial activities were
performed for the essential oil of these species. Each of the four oils showed
multiple biological activities, L. angustifolia, L. hybrida, H. officinalis and P.
frutescens showed antifungal activity against species of candida and L. angustifolia,
L. hybrida, H. officinalis and P. frutescens exhibited moderate anti-microbial
activities. L. angustifolia, L. hybrida, H. officinalis and P. frutescens showed good
anti-inflammatory activities. L. hybrida, H. officinalis and P. frutescens showed
cytotoxicity against various studied cancer cells with different concentrations. It is
possible to view the essential oil of P. frutescens as inspiring natural entities to be
used in the investigation of natural medicines based on the results that were
presented and discussed in this study. Before using them to develop new, effective
drug entities, especially as anti-inflammatory and anti-tumor agents, it is crucial to
subject them to additional biological studies on experimental animals