الفهرس 
Title : Multicomponent Synthesis of Some Novel Bis-Heterocyclic Derivatives
AbstractOnly 14 pages are availabe for public view
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Abstract
Part 1:
A new series of bis(4H-chromene), bis(pyrano[3,2-c]chromene), and bis(pyrano[2,3-c]pyrazole) each
linked to the piperazine core via ether linkages was synthesized. The target compounds are probably
formed through a three-component reaction involving two equivalents of each malononitrile and the
corresponding active methylene compounds, such as dimedone, 4-hydroxycoumarine, or 5-methyl-
2,4-dihydro-3H-pyrazol-3-one. Several spectral methods and elemental analyses were used to deduce
the chemical structures of the novel compounds. Furthermore, all synthesized compounds were tested
for antimicrobial activity, which revealed promising inhibitory results against a variety of multidrugresistant
microbial strains. These findings were compared to those obtained in the in silico molecular
docking study.
Part 2:
The molecular hybridization of various compounds with known pharmacological activity is a
particularly popular approach for the development of potential drugs with improved pharmacokinetic
profiles. In this respect, a novel series of bis(1,4-dihydropyridine-3,5-dicarbonitrile),
bis(decahydroacridine), bis(tetrahydrodipyrazolo[3,4-b:4’,3’-e]pyridin), tetrahydropyrimido[4,5-
b]quinoline, and bis(tetrahydropyrimido[4,5-b]quinoline-2,4,6-trione) derivatives linked to piperazine
core via phenoxyethanone linkages were prepared via Hantzsch like reaction of the ((piperazine-1,4-
diylbis(2-oxoethane-2,1-diyl))bis(oxy))dibenzaldehydes, with the appropriate active methylene
containing reagents. Attempted synthesis of the target products via bis-alkylation of the appropriate
phenol with 1,1’-(piperazine-1,4-diyl)bis(2-chloroethan-1-one) in different basic conditions were
unsuccessful.