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العنوان
The possible effect of certain natural products in chemically induced ulcerative colitis in rats /
الناشر
Yomna Tantawi Abdou Ahmed ,
المؤلف
Yomna Tantawi Abdou Ahmed
هيئة الاعداد
باحث / Yomna Tantawi Abdou Ahmed
مشرف / Sanaa Abdelbaky Kenawy
مشرف / Hala Fahmy Zaki
مشرف / Sanaa Abdelbaky Kenawy
تاريخ النشر
2015
عدد الصفحات
125 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الصيدلة ، علم السموم والصيدلانيات (المتنوعة)
تاريخ الإجازة
11/5/2015
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Pharmacology & Toxicology
الفهرس
Only 14 pages are availabe for public view

from 134

from 134

Abstract

The present study was constructed in order to investigate the colonic response to iodoacetamide (IA) injection as a model for induction of UC in rats. The aim was extended to study the possible protective effects of GSE, NG and EA in comparison with sulfasalazine, as a standard anti-inflammatory drug, on IA-induced UC in rats. To achieve the goals of the present study, inflammatory markers such as colonic contents of prostaglandins E and total nitrate/nitrite as well as inducible 2 nitric oxide synthase were evaluated. Moreover, pro-inflammatory cytokines such as colonic tumor necrosis factor-alpha and interlukin -8 contents as well as colon myeloperoxidase activity as markers for neutrophils infiltration in response to IA were also estimated