الفهرس 
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Abstract
Cholangiocarcinoma is the most common biliary malignancy and the
second most common hepatic malignancy after HCC. It accounts for
approximately 10–25% of all hepatobiliary malignancies. CCA accounts for
about 20% of the deaths from hepatobiliary cancers, which cause 13% of the
total cancer mortality worldwide. Epidemiologic studies suggest that its
incidence has been increasing in Western countries during the last decades.
To identify specific genes involved in the cancer development is crucial
for novel therapeutics development, cancer prevention and early diagnosis. In
recent years, polymorphisms which have been investigated in cell proliferation
and apoptosis of tumors become the new hot spots in tumor molecular genetic
research.