الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
 |  | from | 95 |  |  |
| | | from | 95 | | |
المستخلص
Background : Conventional fractionated radiation therapy over 4-5 weeks with sequential boost is the standard of care for postoperative RT treatment for patients with early stage breast cancer who undergo BCS. However, the use of an accelerated RT course can be used in departments with high patients flow to reduce waiting list and machine loads as well as to improve patient compliance. Patients and Methods: This is a prospective phase II study conducted at Kasr El-aini Center of Clinical Oncology and Nuclear Medicine (NEMROCK). Patients who underwent breast conservative surgery were recruited according to inclusion and exclusion criteria. Recruited patients were planned using 3D conformal technique to receive a hypofractionated radiation schedule using 40 Gy/2.67 Gy per fraction over 3 weeks to the whole breast with Concurrent boost 8.0 Gy/0.5 Gy per fraction over 3 weeks. Dosimetric parameters for the coverage of the breast CTV were set using V38, V36 Gy and the homogeneity using the Dmax and the Dmin. For the coverage of the boost PTV V45.6Gy and V43Gy were used and for dose homogeneity Dmax and Dmin. As regard dose constrain for organ at risk (OAR), no more than 20% of the ipsilateral lung exceeds 16 Gy, no more than 5% of the whole heart exceeds 20 Gy. All patients was evaluated for acute toxicity and cosmetic outcome