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Abstract
Background: Ovarian cancer is the seventh most common cancer in women worldwide (the 18th most common cancer overall), it represents about 3.6% of all cancers in females. Ovarian cancer is diagnosed annually in about quarter of a million females worldwide, and is responsible for 152,000 deaths per year. The risk of ovarian cancer varies across the world, the higher incidence is observed in developed countries as Northern Europe (11.3/100,000) and Northern America (10.7/100,000). The age standardized rate of ovarian cancer is about 6.1 per 100,000. Incidence of ovarian cancer increase after the onset of menopause. According to the National Population-Based Cancer Registry Program in Egypt (2008 {u2013} 2011); ovarian cancer is the fourth most common cancer among females with crude and age standardized incidence rates (4.6 and 6.3) per 100,000 population, respectively. Aim: The aim of the study is to evaluate the relationship between passive smoking (including poly aromatic hydrocarbon) exposure and risk of ovarian cancer. Subjects and methods: A case control study was conducted during the period from July 2016 to December 2016. It was conducted on 79 cases with confirmed ovarian cancer recruited from the National Cancer Institute, Cairo University, Egypt. 79 controls were recruited from visitors attending to the National Cancer Institute, who are relatives to other patients rather than ovarian cancer cases, controls are matched to cases as regard age. Subjects who agreed to participate signed a consent form and answered a data collection sheet. The results: Passive smoking is associated with increased risk of ovarian cancer. Premenopausal women who are exposed to passive smoking are at ii risk of developing ovarian cancer 17.9 times more than those who are not exposed to passive smoking. While postmenopausal women who are exposed to passive smoking are at risk of developing ovarian cancer 3.5 times more than those who are not exposed to passive smoking. Conclusion: passive smoking might be a risk for ovarian cancer