الفهرس 
Salvary cortisol level as an index of pain in mechanically ventilated preterm neonates
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Abstract
Saliva sampling is reliable, non-invasive method to measure biologically active, unbound plasma of cortisol in infants and children. Salivary testing offers advantages over venipuncture since it is noninvasive and less likely to confound results. Also, multiple samples can be obtained without increasing ethical concerns. Aim of study: We used salivary cortisol sample as an index of pain in mechanically ventilated preterm neonates to assess pain and know the effect of different reasons of intubation on the level of salivary cortisol Patients and Methods: Our study was conducted in Abo El Rish Children hospital-Cairo University in the period from June 2015 to December 2015, included 40 preterm neonates between 33-36 weeks gestational age admitted to Neonatal Intensive Care Unit (NICU). Cortisol levels were determined using enzyme-immune assay. Samples were collected without use of stimulants. Results: Our results showed o Significant increase in salivary cortisol level after 30 minutes of intubation with P value less than 0.001 o The cause of intubation has no significant relation with the level of increase in salivary cortisol with P value 0.078 Conclusion: salivary cortisol is considered a good indicator of pain in preterm neonates