الفهرس 
Evaluation of hepatocyte growth factor (HGF) level in ascitic fluid as a marker for diagnosis of spontaneous bacterial peritonitis in cirrhotic patients
تقييم مستوي عامل نمو الخلايا الكبديه في السائل الاستسقائي كدليل لتشخيص الالتهاب البريتوني البكتيري التلقائي في مرضي التليف الكبدOnly 14 pages are availabe for public view
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Abstract
Spontaneous bacterial peritonitis (SBP) is a common and potentially fatal bacterial infection in patients with decompensated cirrhosis and ascites. Hepatocyte growth factor (HGF) levels are regulated under different conditions, for example, during the course of pregnancy, aging and infectious disease. This study focuses on the levels of HGF in ascitic fluid of cirrhotic patient to correlate between the HGF level in ascitic fluid and the diagnosis of spontaneous bacterial peritonitis (SBP) in those patients. A total of 40 patients with SBP were recruited. Ascitic fluid sample from these patients were obtained and compared to ascitic fluid sample from 40 cirrhotic ascitic patients without SBP for HGF level. There was a highly significant statistical difference of HGF levels in ascitic fluid between cirrhotic patients with SBP and those without SBP (P=0.000). The sensitivity and specificity of HGF for selective detection of the SBP group over the non-SBP group were 80 and 82.5%, respectively, at a cut-off value of 2981.34pg/ml. There was a significant positive correlation of HGF levels with TLC in ascitic fluid (r=0.372, p=0.018). There was a significant positive correlation of HGF levels with both ALT levels (r=0.359, P=0.023) and AST (r=0.423, p=0.007) in cirrhotic patients with SBP. We concluded from this study that HGF can be used as biomarkers for early detection of SBP in cirrhotic patients, especially if their values match the cut-off levels detected in our study