الفهرس 
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Abstract
Psoriasis is an inflammatory disease affecting mainly skin and joint with a bimodal age of onset and affects both sexes similarly. At present, the most accepted theory is that psoriasis is an immunemediated inflammatory cutaneous disease which manifests in a genetically predisposed person exposed to some environmental triggeres. Interleukin-23 (IL-23), a heterodimeric cytokine, shows similar functions to IL-12 in promoting cellular immunity and enhancing lymphocyte proliferation In psoriasis, the IL-23 cytokine plays the main role in its pathogenesis by stimulating the proliferation of IL-17-producing lymphocytes and sustaining the inflammatory respose found in psoriatic plaques. A gene polymorphism also called “sequence variant” is a permanent change in the DNA sequence that makes up a gene. This type of genetic change used to be known as a gene mutation, but because changes in DNA do not always cause disease, it is better called gene variant . Single nucleotide polymorphisms (SNPs) of the interleukin-23 receptor gene (IL23R) has recently been associated with development of different autoimmune disease as Ankylosing spondylitis , Crohn disease , Psoriatic arthritis , Ulcerative colitis and Multiple sclerosis . So, our study aimed to detect the genetic variations of IL-23R gene and the susceptibility for developing psoriasis. Our study included (25) patients suffering from psoriasis (group A) from the outpatient clinic of Dermatology Department of Beni-Suef University Hospital and (25) apparently healthy individuals of matched age and sex as a control group (group B) We found that there is no statistically significant differences in genotypic distribution of (rs1884444) among psoriasis cases and control group (p = 0.440) but there is a significant association between disease course and the genotype of (rs1884444) , patients with TT genotype had a progressive course while all GG genotype patients had a remission and exacerbation course. (p-value= 0.040).