الفهرس 
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Abstract
The present study aimed to investigate the potential of type 1 DM (T1DM) recovery through the engraftment of undifferentiated bone marrow MSCs (BM-MSCs) against diabetes-induced changes in nasal cavity vasculature in albino rats. The experiment was carried out on thirty adult male and female albino rats weighting (180-200) gm. They were divided into 4 groups; control group (5 female rats), diabetic group injected intra-peritoneal with 60 mg/kg streptozotocin (STZ) (10 female rats), diabetic treated with 3×106 of undifferentiated BM-MSCs I/V single dose (10 female rats), and BM-MCs donating group (5 male rats). BM-MSCs were isolated, cultured, and characterized by flow cytometry. The pancreatic and nasal cavity tissues samples from all experimental groups were excised and prepared for histological, histochemical, immunohistochemical, molecular as well as morphometric studies. The results were showed in diabetic untreated that there was a highly significant reduction of pancreatic β cells count, vacuolation, reduction in size of pancreatic islets, and congestion in pancreatic and nasal blood vessels. Moreover, positive PCR product of Sry gene, and highly significant increase in insulin and decrease in VEGF immunoreactivity in diabetic group treated with BM-MSCs.