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Abstract
Aims: The deleterious effect of gamma radiation on testicular tissue is a challenging problem in nuclear medicine. This study investigated the potential radioprotective and curative effects of Mitoquinol (MitoQ), a mitochondria-targeted antioxidant, against testicular damage induced by gamma irradiation in rats. Main methods: firstly, a pilot study was conducted to select the most effective dose of MitoQ via estimation of sperm features, testicular caspase-3 along with histological evaluation. The investigated doses were (0.5, 1, 2, 5 & 10) mg/kg/day; i.p. for seven days before gamma irradiation (5 Gray as a single dose) and the most effective dose was 2 mg/kg/day. Then, main study was performed where rats were allocated into five groups. The first group served as the control, the second group received MitoQ (2 mg/kg/day; i.p.) for seven days, the third group was exposed to gamma radiation (5 Gray as a single dose), the fourth group received MitoQ prior to irradiation and the last group received MitoQ after irradiation