الفهرس 
Expression of HER2 and SKP2 in neoplastic and non-neoplastic colorectal lesions
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Abstract
Various pathological conditions or a positive personal or family history that predisposes to CRC development are associated with a particular frequency and lifetime risk of disease occurrence. Thus individuals are considered to be at average, increased or high risk. About 70% of CRCs are sporadic, perhaps attritutable to unidentified genetic factors in the context of dietary and environmental factors. Individuals 50 years of age or older are at average risk, with a 5% lifetime risk of developing CRC. The risk increases to 5- 10% in individuals with a personal history of adenoma/sessile serrated polyps, inflammatory bowel disease, or a positive family history of CRC (NCCN Clinical Practice Guidelines in Oncology, 2013.)