الفهرس 
Title : Study of pharmaceutical and photodynamic efficiency of curcumin in drug delivery systems
ContentsOnly 14 pages are availabe for public view
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Abstract
Curcumin is a natural pigment that generates singlet oxygen upon light excitation; hence it can be used as a photosensitizer in photodynamic therapy. The extremely low water solubility and poor systemic bioavailability make curcumin a challenging molecule to be used clinically. In this study two different delivery systems for curcumin were prepared: liposomes and PVP gold nanoparticles. Cur liposomes were prepared by lipid film hydration method. PVP capped gold nanoparticles were prepared using chloroauric acid as a metal precursor and trisodium citrate. The results showed that the Cur liposomes were spherical in shape of size 350±94 nm and uniform size distribution, had high encapsulation efficiency. Also, the results of Cur PVP gold nanoparticles showed that they were spherical in shape of size 23±2.22 nm. The UV-Vis spectrum of Cur PVP GNPs which shows two peaks, the first one at 408 nm and the second one at 525nm which confirms the characteristic peaks for the components in the Cur PVP GNPs complex are intact. In the FTIR spectrum of Cur conjugated with PVP capped gold nanoparticles, there is a shift of O-H (hydroxyl group)