الفهرس 
Assessment of the Role of NOGO Gene Block in Enhancing the Neuro-regenerative Effect of Mesenchymal Stem Cells
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Abstract
Aim: Amyotrophic Lateral Sclerosis (ALS) is a fatal disease. Mesenchymal stem cells (MSCs) have a therapeutic potential in neuronal diseases, factors as NOGO A limit the axonal regeneration. In this study, gene silencing was used to suppress Nogo-A expression in MSCs, augmenting their neuro-regenerative role. Methods: MSCs were cultured from mice bone marrow then transfected with a plasmid coding for NOGO-A gene SiRNA, mouse models of motor neuron degeneration were created, therapeutic role of non-modified and plasmid transfected MSCs were studied and assessed clinically and histologically. group 1 mice received no treatment. group 2 received an IV injection of non modified MSCs and sacrificed 8 days (subgroup 2a) and 15 days (subgroup 2b) following treatment, group 3 received an IV injection of transfected MSCs and were sacrificed 8 days (subgroup 3a) and 15 days (subgroup 3b) following treatment