![]() | Only 14 pages are availabe for public view |
Abstract Breast cancer (BC) is the main cause of cancer mortality in women worldwide. New strategies for treating BC are required for decreasing the toxicity of chemotherapy. Ehrlich carcinoma, mice’s mammary adenocarcinoma, is an undifferentiated carcinoma, characterized by high transplantable capability, no regression, no specific transplantation antigen, rapid proliferation and short life span. Lactoferrin is an 80 kDa iron binding glycoprotein, found in bovine milk, human milk and different exocrine secretions including saliva, tears, bile fluids, mucosal secretions, pancreatic fluids and in neutrophils. Alterations of cellular lactoferrin gene are associated with an increased incidence of cancer. Several studies indicate that exogenous treatment with lactoferrin and its derivatives can efficiently inhibit the growth of tumors and reduce susceptibility to cancer. |