الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The most frequent reason for infravesical blockage in male young children is posterior urethral valves. It is also the most typical cause of obstructive uropathy, which results in renal failure in children. Despite this, prenatal PUV diagnosis has given the chance to prepare for and begin treatment immediately after birth. A variety of problems with the upper and lower urinary tract are caused by PUVs. Aim of the work : Our study is a retrospective cohort study aiming to analyze and detect the predictive factors that affecting the upper and lower urinary tracts in patients with posterior urethral valves managed initially with endoscopic valve ablation in our institution (Urology and Nephrology Centre) between January 2001 to January 2020. Patients and Methods : It is a retrospective cohort study. The study is being included all patients admitted to Urology and Nephrology Centre (UNC) with the diagnosis of PUVs between January 2001 to January 2020 and were managed by endoscopic valve ablation. Univariate and multivariate analyses using logistic regression were performed to identify independent factors of the study outcomes Results A total of 363 patients were included in this study with their baseline demographic data. The median age at presentation was 11 (range:0-144) months. A one hundred seventy four of the patients (48%) were less than 1 year old and 189 (52%) patients more than 1 year old. Patients were followed up for a median of 34 (range 12-299) months. The median of nadir serum creatinine was 0.7 mg/dl (range 0.1- 15 mg/dl). 98 (27%) of the patients had normal serum creatinine levels of baseline and 265 (73%) of the patients had above normal level according to their ages.The median level of last serum creatinine was 0.7 mg/dl (range 0.1- 12.2 mg/dl). While the median value of eGFR at the follow up visits was 97 ml/min/1.73m2 (range 3-294 ml/min/1.73m2). Conclusion : Long-term morbidity related to PUV still represents a heavy burden for these patients. In particular, progression to renal insufficiency and end stage renal disease. Although prognosis has been improved in the past two decades, patients born with PUV are committed to life-long nephrological and urological follow-up, from early after valve ablation till adolescence and adulthood. Recommendations The high prognostic value of nadir serum creatinine, presence of HN and its laterality for renal outcomes evaluation in long term follow up.