الفهرس 
Comparison between the therapeutic effect of albendazole and albendazole conjugated with nanoparticles on different stages of murine Trichinella spiralis infection
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Abstract
Trichinosis is a serious parasitic zoonotic disease caused mainly by Trichinellaspiralis. It is transmitted by ingestion of undercooked pork meat containing encysted Trichinella larvae. The used drugs for treatment of trichinosis showed limited bioavailability and high degree of resistance. Moreover they have a very poor effect in treatment of encysted larvae. Therefore this is urgent need in development of new agents which help in improving the bioavailability of the used drugs and enable them to reach different tissues. This study was designed to assess the use of chitosan nano-particles (CSNPs) in conjugation with full and half dose albendazole (ABZ) in treatment of intestinal and muscular trichinosis. Parasitological and histopathological examinations were used to evaluate the therapeutic efficacy of the used drugs. Albino mice (84 mice) were used to evaluate the efficacy of drugs and divided into seven groups; I: control, II: ABZ (50 mg/kg) treated, III: ABZ (25 mg/kg) treated, IV: ABZ (50 mg/kg) conjugated CSNPs treated, V: ABZ (25 mg/kg) conjugated CSNPs treated, VI: CS treated and VII: CSNPs treated. Results showed significant reduction of adult Trichinella extracted from intestine of all ABZ treated groups either conjugated or not with the highest reduction rate in group IV followed by group V with percentage of reduction of 99.33% and 98.11%, respectively and marked improvement of histopathological examination. Also, results showed significant reduction of Trichinella larvae extracted from muscles of group IV, V and VII with the highest reduction rate in group IV with percentage of reduction of 100% in muscle larvae and marked improvement of histopathological examination. According to results of our study, we can conclude that albendazole full dose conjugated chitosan nano-particles can be a good candidate drug for treating both intestinal and muscular trichinosis