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العنوان
Study of Possible Effects of Ferulic acid and Artichoke Extract on Metalloproteinase Activity in HepG-2 Carcinoma Cell line /
المؤلف
Elnakeeb, Nadia Abdelaziz Abdelmonem Abdelaziz.
هيئة الاعداد
باحث / Nadia Abdelaziz Abdelmonem Abdelaziz Elnakeeb
مشرف / Nabil Mohie Abdelhamid
مشرف / Mohamed Samy El gharieb
مشرف / Fardous Fawzy Elsenduny
مناقش / Ayman Elbaz Elagrody
مناقش / Ahmed Wahid Mahmoud
تاريخ النشر
2022.
عدد الصفحات
233 p. ;
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
Multidisciplinary تعددية التخصصات
تاريخ الإجازة
28/9/2022
مكان الإجازة
جامعة بورسعيد - كلية العلوم ببورسعيد - Chemistry Department
الفهرس
Only 14 pages are availabe for public view

from 233

from 233

Abstract

The current study showed that TFA and CGA, either alone or in combination with CIS, DOXO, and 5-FU, were efficacious in treating HCC. This is accomplished through a number of intracellular pathways, including a significant decrease in the tumour marker AFP, oxidative stress, inhibition of metalloproteinases 3, 9, and 12, cellular migration, and gelatinolytic activities as indices of metastasis. This suggests that both treatments have an ameliorative effect on the tumour cells. Since TFA and CGA have antioxidant effects, we believe that using them as a chemosensitizer may hold new promise in the treatment of HCC and may lessen the toxic side effects of chemotherapy drugs.