الفهرس 
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Abstract
Rift Valley fever (RVF) is a zoonotic disease affecting many types of animals, causing significant economic loss in livestock and transmitted to human, which affects public health. It has been found that the use of vaccines in susceptible animals is one of the most significant factors to control this disease.
The use of nanoparticles in vaccine formulations improves the vaccine quality and raises its efficiency.
This study was conducted to evaluate the biochemical and immunological effects of chitosan and aluminum phosphate nanoparticles as novel adjuvants to enhance the quality of RVF vaccine in regard to vaccine with aluminum hydroxide gel.
Twenty sheep of 3–4 months old were kept in an isolated place and were divided into 4 groups (5 animals/group) as follows:
group 1 : Sheep non-vaccinated (control negative).
group 2 : Sheep vaccinated (S/C) with 1ml of inactivated aluminium hydroxide gel adjuvanted RVF vaccine (AlHV) as one dose.
group 3: Sheep vaccinated (S/C) with 1ml of inactivated chitosan nanoparticles adjuvanted RVF vaccine (Ch-NPsV) as one dose.
group 4: Sheep vaccinated (S/C) with 1ml of inactivated aluminium phosphate nanoparticles adjuvanted RVF vaccine(AlP-NPsV) as one dose.