الفهرس 
Insulin resistanceOnly 14 pages are availabe for public view
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Abstract
Insulin resistance is identified as an impaired biologic response to insulin stimulation of target tissues, primarily the liver, muscle, and adipose tissue. Insulin resistance impairs glucose disposal, resulting in a compensatory increase in beta-cell insulin production and hyperinsulinemia.
Our aim of the study is to study the validity of triglycerides glucose index (TyG) and TG/HDL ratio as markers for insulin resistance (IR) and their correlation with atherosclerotic cardiovascular disease (ASCVD).
Our cross sectional study was carried out on 81 patients informed consent was taken from the patients, all patients included were subjected to detailed history, Complete physical examination and anthropometric measurements.
The studied patients were distributed according to Framingham Wilson score into two groups:
group 1: subjects with score less than 5% in 10 years.
group 2: subjects with score more than 5% in 10 years.
- Laboratory investigations were done including the following:
Complete blood count (CBC), Lipid profile, Renal and liver function tests.
- Specific investigation:
Fasting glucose and fasting insulin.
Triglycerides glucose index (TyG): using the equation = ln [fasting triglycerides (mg / dl) × fasting glucose ( mg / dl)/2]
TG/HDL ratio: was calculated from the division of TG over HDL.
We found that:
There was high significant difference between the studied groups regarding age (p<0.001).
Regarding BMI, there was statistically significant increase of BMI in group 2 compared to group 1 (p<0.001).
Regarding SBP, there was statistically significant increase of SBP in group 2 compared to group 1 (p<0.001).
Regarding FWS there was high significant difference between the studied groups (p<0.001).
Regarding HDL-c:The mean value is significantly higher among group 2 than group 1 (p= 0.032).
Regarding FBS and fasting insulin: The mean value is significantly higher among group 2 than group 1 (p<0.001).
Regarding HOMA-IR: The mean value is significantly higher among group 2 than group 1(p= 0.06).
There was high significant positive correlation between HOMA-IR and BMI, TyG, TG/HDL ,SBP, Framingham score & fasting insulin.
There was high significant positive correlation between Framingham score and age, BMI, SBP, FBS, fasting insulin, TG/HDL, TyG & HOMA-IR.
Regarding TyG: The mean value is significantly higher among group 2 than group 1 (p<0.001).
There was high significant positive correlation between TyG and age, BMI, SBP, FBS, fasting insulin, TG/HDL, TyG & HOMA-IR.
Regarding TG/HDL: The mean value is significantly higher among group 2 than group 1 (p<0.001).
There was high significant positive correlation between TG/HDL and age, BMI, SBP, FBS, fasting insulin, TyG, Framingham score & HOMA-IR.