الفهرس 
Title : Salsabeel Ali Mahmoud Afifi; Sensitivity and specificity of serum and salivary Cyfra21-1 in the detection of malignant transformation in oral potentially malignant mucosal lesions: Diagnostic accuracy study
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Abstract
Aim: The aim of the current study was to identify the specificity and sensitivity of CYFRA21-1 in differentiating between oral malignancy and oral potentially malignant lesions (PML) in order to be able to early diagnose malignant changes in oral lesions. Methodology: 28 subjects were divided into 3 groups. The first group included 12 patients suffering from oral PML; 8 oral lichen planus (OLP) cases and 4 with leukoplakia. group II included 8 patients who suffered from oral cancer in various locations. The control group involved 8 healthy subjects. Serum and salivary CYFRA21-1 concentrations were measured using enzyme linked immunosorbent assay (ELISA) technique (index test). Results of ELISA were correlated with the histopathological examination of biopsy specimens (reference standard) taken from patients of groups I and II. Results: Oral cancer showed the highest levels of CYFRA21-1 in both saliva and serum followed by PML and then the control group where the differences in means were statistically significant. OLP and leukoplakia showed no statistically significant difference between them in both serum and salivary CYFRA21-1 levels. Conclusion: Serum and salivary CYFRA21-1 could be considered promising biomarkers for the diagnosis of oral malignancy and its discrimination from PML. Thus, they could be helpful in detection of early malignant changes in PML especially OLP and leukoplakia