الفهرس 
Title : Anti-Mullerian Hormone And Inhibin B As A Diagnostic Replacement Of Human Chorionic Gonadotropin Stimulation Test In Evaluation Of 46 XY Disorders Of Sex Development
AbstractOnly 14 pages are availabe for public view
 |  | from | 158 |  |  |
| | | from | 158 | | |
Abstract
Objective: To assess the role of anti- Mullerian hormone (AMH) and inhibin-B in diagnosis of 46, XY disorders of sex development (DSD) in comparison to HCG stimulation test. Patients and methods: The study was conducted on 42 patients diagnosed as 46 XY DSD comparing them with 42 healthy male age matched control group attending DEMPU, New Pediatric Hospital, Cairo University.The median age of the studied cases was 4 years.The following investigations were performed for all patients; karyotyping, ultrasonography, laboratory investigations included HCG stimulation test and measurement of basal AMH and inhibin B. Results: The median level of AMH in testicular agenesis/dysgenesis group was 26.7ng/ml while it was 84ng/ml in the other subgroups of 46 XY DSD with statistically significant difference between them (p{u02C2}0.001).There were significant correlations between basal AMH and HCG stimulated testosterone and DHT (r = 0.571; p < 0.001 and r = 0.452; p =0.004 respectively). No significant correlations were found between inhibin B and HCG stimulated testosterone and DHT (r = 0.075; p = 0.649 and r = 0.226; p = 0.198 respectively). At a cut-off value of (43.2ng/ml), the sensitivity of AMH was (90.9%), specificity (96.8%), NPV (90.91%) PPV (96.77%), with overall accuracy (95.24%) to detect the presence of functional testicular tissue. While the inhibin B showed no discrimination between subjects who had functioning testicular tissue from those who had not