الفهرس 
Title : valuation of serum taurine as a prognostic marker for graft function in adult Egyptian patients undergoing living donor liver transplant
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Abstract
Background: Taurine has been investigated as a potential screening marker for early diagnosis of hepatocellular carcinoma and other liver diseases. This study was conducted to evaluate serum taurine as a potential prognostic marker for graft function in Egyptian patients undergoing living donor liver transplant.Aim: A Prospective study to correlate between serum taurine level of adult Egyptian patients undergoing living donor liver transplantation and graft function.Methods: A prospective cohort study was conducted during August 2019 to May 2020. We measured serum taurine levels using high performance liquid chromatography in patients with end- stage liver disease who were candidates for living donor liver transplant before transplant, then on the 7th, 14th, and 30th day post-transplant. Patients were followed up to detect graft dysfunction, Seventh Day Syndrome, and the 30-day mortality. Results: Sixty patients were enrolled in this study. Preoperative serum taurine levels did not correlate significantly with liver function tests, and its predictive performance for primary graft dysfunction and 30-day mortality was poor (area under curve [AUC]=0.662; p=0.038 and AUC=0.642; p=0.202, respectively). Serum taurine level at the 7th post-transplant day had good diagnostic performance for primary graft dysfunction (AUC=0.827; p<0.001) and good predictive performance for 30-day mortality (AUC=0.888; p<0.001).Only two patients with taurine level<30 omL-1 developed Seventh Day Syndrome