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Abstract Background: Polycystic ovary syndrome (PCOS) is considered as one of the most common endocrine disorders in women of reproductive age with a strong genetic component, Aim and objectives: The main aim of this study was to assess the effect of oral supplement of vitamin D in patients with clomiphene citrate resistant PCOS, Subjects and methods: this was a clinical trial study was conducted in infertility clinic in Ain Shams Maternity Hospital including 130 women who were: PCOS in child bearing age (from 18 to37 year-old), With body mass index from 25 to 35 & Clomiphene citrate resistant that means failure to ovulate with 3 months of usage of CC at 150 mg /day for 5 days. The duration of the study ranged from 12 months, Results: As regard to ovulation-post-treatment, 29 (29%) patients could ovulate. As regard to pregnancy rate, 12 (12%) patients were positive and 88 (88%) patients were negative, Conclusion: supplementation with oral vitamin D improved fertility outcome. |