الفهرس 
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Abstract
Lung cancer and lung fibrosis are main topics in chest diseases that have been reported to be associated with each other.
Our thesis objectives were to study the incidence rate of lung cancer on top of established lung fibrosis, assessing the common mediators causing both of them, type of malignancy developed and the diagnostic tools for early detection of lung cancer.
This current prospective cohort and retrospective study was conducted on 100 patients assessed by HRCT chest and histopathological tests for diagnostic purposes.
Data collected from patients included patients demographic data, complete blood count, erythrocyte sedimentation rate, liver function tests, kidney function tests, bleeding profile , chest high resolution computed tomography and tissue histopathology.
Patients were categorized in two groups:
Group1: 50 patients diagnosed as lung fibrosis and investigated for lung cancer development.
Group2: 50 patients diagnosed as lung cancer and investigated for lung fibrosis background.
• One hundred patients were included in the study.
• Their mean age was 51.10±15.9 in the range of (17 – 79 years old) in group 1 and 59.10±11.7 in the range of (29 – 88 years old) in group 2.
• Twenty four of included patients were males (48%), the remaining twenty six were females (52%) in group1and thirty six of patients in group 2 were males (72%), and the remaining fourteen were females (28%).
Seventeen of included patients were smokers (34%) in group 1 and forty four were smokers (88%) in group 2.
• Ten of included patients (20%) had occupational exposure to carcinogenic inorganic dust in group1and only 2(4%) in group 2.
• Radiological findings were categorized as; two (4%) mass&reticulonodular pattern, twenty six(52%) ground glass appearance, twenty two (44%) reticulonodular pattern in group1 and eight (16%) mass&reticular pattern ,fourty two (84%) mass in group2.
• Nature of biopsy was divided into; fourteen (28%) Bronchoalveolar lavage, twenty six (52%) sputum cytology, three (6%) Bronchoscopic biopsy, three (6%) CT guided biopsy and four (8%) US guided biopsy in group 1. Twenty (40%) Bronchoscopic biopsy, sixteen (32%) CT guided biopsy and fourteen (28%) US guided biopsy in group 2.
• Histopathological findings was found as; fourty eight (96%) inflammatory, one (2%) adenocarcinoma and one (2%) squamous cell carcinoma in group1. Twenty one (42%) adenocarcinoma, eight (16%) squamous cell carcinoma, twelve(24%) small cell carcinoma and nine(18%) large cell carcinoma in group2.
• There is highly significant statistical difference between the two groups regarding their sociodemographic and clinical data, their radiological findings, their nature of biopsy and their histopathological findings.
• There is significant statistical difference between the two groups regarding the laboratory tests (CBC&ESR).
• There is significant statistical difference between the two groups regarding relation between radiological finding and histopathological finding.