الفهرس 
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Abstract
This present study aimed to evaluate immune staining expression of IFN-γ and IL-15 in patients with AA and healthy subjects assessing their relationship to clinical parameters of the diseases.
The study was a Case-Control study conducted from February 2020 to February 2021 in the Dermatology outpatient clinic at Beni-Suef University Hospital. This study included conducted on thirty-six patients with Alopecia Areata (AA), (36 Tissue samples from AA lesions and other 36 Tissue samples from healthy skin as control samples from the same patients).
Written Informed consent had been taken from all studied participants prior to beginning of the study. All participants were subjected to full clinical and laboratory investigations. Skin biopsies had been taken from all studied participants to to evaluate immune staining expression of IFN-γ and IL-15 in patients with AA.
Our data analyses reveled that immune staining expression of IFN-γ in skin lesions with AA showed higher scores as compared with healthy skin among studied participants. Also, immune staining expression of IL-15 in skin was slightly higher in AA skin lesions as compared with healthy skin but without a statistically significant difference.
All the examined samples with IFN-γ Score +4 showed positive IL-15 expression with a statistically significant difference which mean that there is a statistically significant association between immune staining expression of IFN-γ and IL-15 in skin lesions with AA.
As regards the association between SALT score with interleukin-15 tissue expression in AA patients, SALT was significantly higher among studied samples with positive IL-15 expression.
There was a statistically significant positive linear correlation between SALT score and IFN-γ tissue expression in AA patients there was non-statistically significant negative linear correlation between patients’ age and IFN-γ tissue expression in AA patients
We concluded that; the elevated tissue level of IL-15 and IFN-γ in patients with active AA might suggest its role as an important signaling cytokines in the pathogenesis of AA. There levels are influenced by disease severity which might reflect disease prognosis.