الفهرس 
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Abstract
OSCC is responsible for more than 90% of all oral cancers and is one of the most aggressive diseases worldwide. It is generally accepted that the majority of OSCCs arise from precursor lesions collectively called OPMDs. Use of biomarker Survivin in OPMDs such as OLP may provide advantage in early diagnosis, assessment and prognosis of OLP. Survivin (anti-apoptotic protein) is known to be responsible for tumor cell viability, resistance to apoptosis and magnification of tumor progression. Survivin expression together with its cellular localization should be considered to evaluate its impact on future prognosis and therapy options.
CAMs govern the social behaviors of the cells. The altered expression of CAMs affects cell-cell interactions and cell-extracellular matrix interactions which results in changing the cellular motility and invasiveness. Altered expression of CAMs also can affect survival and growth of tumor cells and correlates with the malignant progression of many epithelial tumors.
This study was carried out to investigate, immunohistochemically, Survivin and CD146 expression in OLP and different grades of OSCC and to detect if a possible correlation exist between the expression of Survivin and CD146 in both lesions.
The material of this study consisted of fifty formalin-fixed, paraffin-embedded specimens of OLP and OSCC (twenty five of each). Immunohistochemical staining using the anti-Survivin antibody and the anti-CD146 antibody was performed by the biotin-streptavidin immunoperoxidase technique. The immunostained slides were examined by light microscopy and photographed. The photomicrographs were then analyzed using image analysis software. For all positive cases, the area fraction of immunopositivity for four different microscopic fields was measured. The mean area fraction for each case was then calculated to be used for statistical analysis.
Immunohistochemical results of the present study revealed 100%, Survivin immunopositivity in all cases of OLP and OSCC while not all cases were CD146 immunopositive.
Survivin expression in OSCC was higher than OLP with a statistically significant difference. Moreover, a highly statistically significant difference existed between different groups of OSCC.
CD146 expression in OLP was higher than OSCC with a statistically significant difference. Moreover, a highly statistically significant difference existed between different groups of OSCC.
According to the obtained data, it could be concluded that Survivin can be used as an early biomarker for malignant transformation of OLP into OSCC and a prognostic marker of OSCC. CD146 expression may underlie the progression of OLP into OSCC. There was a highly significant inverse correlation between apoptosis and invasiveness through progression of OLP into OSCC.