الفهرس | Only 14 pages are availabe for public view |
Abstract Objective: to assess the clinical value of daily serum PCT measurements for guiding the initiation of antibiotic treatment in intensive care patients with SIRS without evident infection and compare it with empiric antibiotic administration on admission. Patients and Methods: This randomized double blinded prospective controlled clinical study was conducted on 72 patients with SIRS without evident sepsis admitted to the intensive care unit of the obstetrics and gynecology hospital in Ain Shams University Hospitals from October 2018 to December 2020. Results: Procalcitonin level was elevated above the cut off value of 2 ng/ml in 15 patients in the PCT-guided antibiotic therapy group and 11 patients in the empiric antibiotic therapy group. Procalcitonin elevation above 2 ng/ml in the surgical subset was more significant than in the medical subset in both groups. The SOFA score and the length of ICU stay were not statistically significant different between the two groups. Conclusions: Postponing antibiotic therapy in patients admitted to ICU with suspected noninfectious SIRS until PCT is higher than 2 ng/ml is safe especially in medical ICU. |