الفهرس | Only 14 pages are availabe for public view |
Abstract The aim of this study was to evaluate serum adiponectin level in obese patients with gastroesophageal reflux disease and barrett’s esophagus. This study was conducted on 120 participants included 60 patients with GERD, 30 patients with Barrett esophagus as well as, 30 participants of matched age and sex as controls. All participants were selected with BMI ≥25. Patients and controls were selected from Tropical Medicine department Menoufia university hospital and Shebin El-kom Teaching hospital in period between October 2018 to April 2020. Patients were 48 males (53.3%) and 42 females (46.7%). Their ages were ranging between 27 – 64 years old. Also, control group was 17 males (56.7%) and 13 females (43.3%). Informed consent was obtained from all participants in accordance with local ethical committee. Patients and controls were classified in to the following groups: group (I): Included thirty obese persons without GERD as control. group (II): Included sixty obese patients with GERD. group (III): Included thirty obese patients with Barrett esophagus. All subjects were subjected to the following: Full history taking, physical examinations and laboratory investigation with measurement of serum adiponectin by ELISA, upper GI endoscopy and histopathological examination for biopsies taken from query barrett lesions. Statistical analysis of the presenting data revealed: • In the present study no statistically significant difference between groups as regard age and gender, also, regarding smoking as special habit most of patients in group (ІІ) and group (ІІІ) in comparison with control group (І) are smokers. • In present study fasting blood glucose was higher in group (II) than group (III) with statistically signifigant difference between the three studied groups which means that obese patients are more liable to develop GERD and diabetes mellitus as a part of metabolic syndrome. • In present study no statistically significant diffrernce between the three studied groups regarding different anthropometric measurements, BMI and midarm circumference. While, there was statistically significant diffrernce between the three studied groups regarding waist/hip ratio. • In present study no statistically significant difference between the three studied groups regarding hemoglobin concentration, white blood cell count, platelets count, ALT, AST as well as, no statistically significant difference regarding total cholesterol and triglycerides. • Regarding lipid profile, this study showed a significant increase in serum cholesterol and triglycerides in all groups which means that obese patients are more liable to develop GERD and dyslipidemia as a part of metabolic syndrome. • Also, in our study we found an inverse relationship between plasma adiponectin and serum triglyceride levels as well as, fasting plasma glucose concentrations. |