الفهرس 
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Abstract
Prosate cancer is an important health problem. It is considered the second most frequent cause of cancer-related death in men.
DW MRI in the prostate is a relative new and frequently used imaging technique. It has the advantage that it can be obtained during a single breath-hold, there is no need to use contrast media and it provides unique information that reflects tissue cellularity and organization. The ADC maps can also provide quantitative measurements of tissue water diffusivity, which can be used not only for disease assessment, but also for the evaluation of disease response to treatment.
In our study we examined 25 cases underwent DWI MRI before TRUS guided biobsy and our results showed that the sensitivity of MRI diffusion in detection of malignant prostate masses was 71.4% its specificity was 94.4% %, the PPV was 83.3% and the NPV was 89.5%.
In our study we concluded that diffusion-weighted MRI sequence with quantitative ADC measurements can be useful in taking extra samples from the suspicious lesions detected by diffusion MRI prior to prostate biopsy
DWI proved to be helpful in the characterization of prostatic lesions, but should always be used in conjunction with traditional MRI since there is great overlap between ADC values of benign and malignant lesions. It seems reasonable to use DWI in conjunction to conventional imaging.
Our study suggested that at a cut off value of PSA 13 we can predict the malignancy with 57.14% sensitivity, 88.9% specificity, 66.7 Positive predictive value and 84.2 negative predictive value.
The accurate detection and localization of prostate cancer before a biopsy would likely decrease the excessive biopsy rate. So we increase diagnosis rate of prostate cancer after using transrectal ultrasonography (TRUS) guided biopsy samples from pre-determined lesions in diffusion-weighted magnetic resonance imaging (MRI).