الفهرس 
Acute Myeloid leukemiaOnly 14 pages are availabe for public view
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Abstract
Background: Acute myeloid leukemia (AML) is a disorder characterized by a rapid onset of symptoms attributable to bone marrow failure due to clonal proliferation of primitive hematopoietic stem cells or progenitor cells. Epigenetic abnormalities play an important role in the development and progression of acute leukemia. Long non-coding ribonucleic acid (lncRNA) plays an important role in epigenetic regulation. Homeobox (Hox) transcript antisense intergenic RNA (HOTAIR) is a lncRNA which has been determined to be a negative prognostic indicator in various solid-tumor patients. However; its role in hematopoietic tumors as AML is to be assessed. This study aimed at measuring lncRNA HOTAIR in newly diagnosed AML patients and correlating its expression with different clinicopathological prognostic variables. This provides a new prospective for novel marker involved in development and progression of AML which can be used as diagnostic marker and target of therapy. The current study included 65 subjects divided into 35 newly diagnosed AML adult patients (before initiation of therapy) and 30 non-leukemic adult patients as controls. HOTAIR expression was measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR).
Results: HOTAIR expression was found to be significantly upregulated in AML patients (p = 0.000) and showed to have a diagnostic ability of AML as confirmed by significant difference between cases and controls using receiver operating characteristic curve (ROC) analysis. However; it was not significantly correlated with event free survival (EFS) or clinicopathological prognostic variables.
Conclusion: This study showed that the expression of HOTAIR is upregulated in de novo AML patients and can be used as a diagnostic marker. However; high¬ly expressed HOTAIR is not associated with poor prognosis.