الفهرس 
Introduction And RationaleOnly 14 pages are availabe for public view
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Abstract
Magnesium sulfate is a cornerstone therapy, both for the prevention and treatment of eclamptic seizures and a tocolytic agent in preterm labor. Clear evidence showed that it is safe and that its use leads to a significant reduction in the risk of seizures and maternal death.
The present study aimed to improve the fetal outcome in cases of pregnant women with pre-eclampsia and pregnant women with preterm labor through evaluating the effect of magnesium sulfate administration on doppler velocimetric parameters (resistance index [RI] and systolic/diastolic [S/D] ratio) of the umbilical artery.
Forty pregnant women who fulfilled the inclusion criteria; group 1 was twenty women with severe preeclampsia and group 2 was twenty women with preterm labor with gestational age more than 28 weeks.
Magnesium sulfate was administered in both groups(40 cases) according to protocol of management in emergency unit as a loading dose of 4 g of the drug mixed in 100 mL of 5% dextrose solution, intravenously over 15 to 20 minutes. Doppler studies were done twice before and after administration of the loading dose of magnesium sulfate.
After administration of a loading dose of magnesium sulfate, the resistive index of the umbilical artery doppler in women with severe preeclampsia decreased from 0.59 (0.51 – 0.75) to 0.54 (0.41 – 0.69) & the S/D ratio decreased from 2.53 (2.08 – 4.1) to 2.25 (1.7 – 3.10).