الفهرس 
Intra Uterine Growth Retardation (IUGROnly 14 pages are availabe for public view
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Abstract
Maternal Vitamin D deficiency and Intra Uterine Growth Retardation
Hisham Mohamed Fathi, Ahmed Mohamed Bahaa Eldin Ahmed, Waleed Mohamed Khalaf, Mohamed Elsaid Elsaid Elsegeny
Department of Obstetrics and Gynaecology, Faculty of Medicine – Ain Shams University
Corresponding author: Mohamed Elsaid Elsaid Elsegeny, Mobile: 01220541746;
Email: m_elsegeny@yahoo.com
ABSTRACT
Background: Vitamin D has an increasingly recognized non classical actions such as promoting insulin action and secretion, immune modulation and lung development. It has the potential to influence many factors in the developing fetus. Vitamin D deficiency may be a critical risk factor linking maternal in utero growth and pregnancy outcomes. Possible mechanisms for associations between poor intrauterine growth and adulthood vitamin D deficiency involve reduced vitamin D binding protein, reduced renal function and genetic variations that influence both fetal growth and vitamin D homeostasis.
Objective: To investigate the vitamin D status and find if there is an association between maternal vitamin D deficiency and intra uterine growth retardation (IUGR).
Patients and Methods: Our study is case-control study which conducted at Ain Shams Maternity Hospital obstetrics clinics from February 2019 to August 2019, it included 80 pregnant women (40 of them were with intra uterine growth retardation and the other 40 were normal) who are singleton pregnancy with any parity, gestational age between 28-34 weeks and their ages vary from 20-35 years old after excluding of pre eclampsia or eclampsia, DM, hepatic failure, chronic kidney disease, drug abuse(cocaine), multiple pregnancy, congenital fetal malformation, antiphospholipid syndrome, systemic lupus erythematosus and thrombophilias. During the routine antenatal care, 5ml of maternal blood withdrawn to assess maternal 25-OH vitamin D status using ELISA technique.
Results: Our study showed the strong relation between maternal vitamin D status and the intra uterine growth retardation. Results here revealed that maternal hypovitaminosis D is associated with intra uterine growth retardation.
Conclusion: This study shows association between maternal vitamin D deficiency and intra uterine growth retardation. Maternal vitamin D level should be measured during pregnancy.