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Abstract Summary Trichinellosis is one of the cosmopolitan zoonotic parasitic diseases. It is caused by parasites of the genus Trichinella. Trichinella spiralis (T. spiralis) is the most common species of Trichinella infection in wild and domestic animals. Moreover, it may cause human infections all over the world (Lo et al., 2009). The infection is caused by ingestion of raw or undercooked meat containing the encysted larvae from infected animals; mainly pigs (Onkoba et al., 2015). T. spiralis infection induces an intense inflammatory response and functional changes in the motility of the small intestine. It destroys the epithelial cells they occupy. On the contrary, the immune response in the small intestine may make that site inhospitable to the worms. The inflammatory response caused by the invasion of the muscles by the migrating larvae leads to damage of the muscle cells and loss of the myofibrils (Wu et al., 2012). The nurse cell is formed around the muscle stage larva of T. spiralis with development of a capillary network around the infected cell (Dupouy-Camet and Bruschi, 2007). Albendazole and mebendazole are widely used in the treatment of trichinellosis with a high therapeutic index and low toxicity. Albendazole has the slight advantage (Kadry et al., 2005 and Gottstein et al., 2009). The anti-inflammatory treatment during trichinellosis includes the usage of steroid; but their side effects limit their usage as they |