الفهرس 
Anticancer activity:Only 14 pages are availabe for public view
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Abstract
Natural products remain a rich source of novel molecular scaffolds and
neocryptolepine 1, and cryptolepine 2 an indoloquinoline alkaloid extracted
from the roots of cryptolepis sanguinolenta are examples of natural products
with wide biological activity. Besides their extraction from natural sources,
several synthetic methodologies have been developed and novel
neocryptolepine 1 and cryptolepine 2 derivatives with improved biological
activity have been reported from our group and others. Prompted by these
results, the main objective of this thesis work is to synthesize novel derivatives
of the anticancer natural compound neocryptolepine 1 as part of a larger
project of development of safer and potent anticancer drug candidates, at an
affordable cost. The proposed approach is to synthesize neocryptolepine
conjugates with an aminophosphonate 3, acridine 4 and rhodanine 5
surrogates, which are expected to improve the anticancer activity and the
selectivity against cancer cells