الفهرس | Only 14 pages are availabe for public view |
Abstract Protozoan diseases remain a major global health problem, especially in tropical and subtropical countries. Many of these diseases are endemic and recognized as epidemiological priorities by the World Health Organization (WHO). < Malaria, leishmaniasis and toxoplasmosis are common examples to widespread parasitic infections. Currently, the drugs used in the treatment of these diseases encountered major limitations, such as resistance, toxicity, cost extravagance and patient intolerance. There is therefore an urgent need for suitable drug offering the following: low-cost manufacturing, innovative structure to overcome drug resistance and wide therapeutic range. In addition, It is well known that 1,3-diaryl pyrazole derivatives displayed a wide array of biological activities including antiprotozoal potential. Consequently, and as a continuation to our program, the present study was oriented toward the design and the synthesis of some new pyrazole derivatives based on the hybridization with heterocyclic scaffolds such as, Nsubstituted pyrazolines, pyrazolinones and 1,2,4-triazoles. The hybrid molecules were attached directly or through different spacers (from 1-4 atoms). <Also, some small hydrophilic and lipophilic functional groups were inserted at pyrazole-C4 or as a side chains such as oximes, carbonitriles, carboxylic acids, carboxamides, and substituted amides, in addition to various hydrazones and acrylic acid derivatives in which comparative studies for their antimalarial, antileishmanial and anti-toxoplasma activities were established. |