الفهرس 
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Abstract
Obesity is threatening public health worldwide; it is a very strong risk for diabetes mellitus. Deposition of lipids in the visceral abdominal adipose tissue induces hypertension, insulin resistance and so hyperglycemia and diabetes with hyperlipidemia. There is an update for dietary change, Exercise and calorie intake control. One of the most recent effective agents for controlling obesity are the natural agents originate from plants, like ephedrine and caffeine, p-synephrine, and of wide range world wide use is forskolin (FSK) (Coleus root extract). Forskolin (FSK) is a diterpenoid extracted from plant Coleus forskohlii. It stimulates adenylate cyclase (AC). Forskolin (FSK) as a natural agent gain a lot of famous in the last few days after many TV shows that talk about its benefits to lower blood pressure and improve heart beats, treat glaucoma, overcome colon cancer and treat skin lesion. Recently; it was discovered that it can reduces body weight, reduces body weight gain and increases fat loss and hydrolysis from adipose tissue. In the fact; there are little literatures prove its action on stored lipids. Only few studies address this subject. This gives us the impetus to study its effect on body lipids status through the following.
The study was conducted on forty male albino rats weighting at the start of experiment 200-250 grams. The rats were housed in stainless cages with optimum light/dark cycles, temperature and humidity. After one week of acclimatization rats were randomly classified into four main groups of tens in each group as the follow; group A; rats were received normal diet (standard diet for rats) they did not expose to any type of treatment and were served as a control group; group B; rats that received high fat diet for ten weeks (fattening period); and this group was served as high fat-diet (fattened group), group C; rats that received high fat diet with FSK (100% FSK extract 0.5 mg/kg/day) for ten weeks (this group received FSK during induction of obesity), group D; rats that received high fat diet for ten weeks (fattening period) and then received FSK (100% FSK extract 0.5 mg/kg/day) for excessive two weeks (this group received FSK after inducing of obesity; then the fattening diet has been stopped and continued to receive normal diet with FSK for two weeks). At the end of experimental period blood and omental adipose tissue samples were collected preserved and used for biochemical determination of lipid profile and mRNA expression profile of adenylate cyclase and hormone sensitive lipase respectively. The results were obtained statistically analyzed and then tabulated.