الفهرس | Only 14 pages are availabe for public view |
Abstract Major features of polycystic ovarian syndrome (PCOS), a common disorder affecting women of childbearing age, include oligomenorrhea or amenorrhea with clinical or laboratory signs of hyperandrogenemia. Cabergoline, ergot-derived dopamine agonists with a very long half-life, is an effective prolactin suppressor. Doppler analysis and color flow in PCO: It have been shown that in women with PCOS, important changes in ovarian vascularization occur at the level of the intraovarian arteries. In our current study which assess the effect of Cabergoline administration on uterine perfusion and ovarian stromal blood flow using Doppler ultrasound. We involve 104 women suffering from PCOs attending to department of Obstetrics and Gynecology of outpatient clinic of Shibin El Kom Teaching Hospital. The women were selected according to Rotterdam criteria as mentioned before, age between 20 to 40 years. All participants attend to perform Doppler ultrasound examination in the early follicular phase (2nd to 6th day) of a spontaneous menstrual period in women with regular cycle or a withdrawal bleeding in women with long irregular cycle and all data was recorded. 50 women (patients) were received Cabergoline 0.5mg per week for 3 months and 54 women (control) didn’t receive any drug. At the end of 3rd month another Doppler U/S were performed to all women and the results were recorded. In summary, administration of Cabergoline in PCOs women by 0.5 mg/week for 3 months improves the uterine and ovarian stromal indices. This may be one of the possible mechanisms by which Cabergoline improves . |