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Abstract In this study hematological, biochemical and some oxidative steers parameters were evaluated for 75 pesticide handlers or occuptionely-exposed workers in different pesticide exposure fields (industry, transport, storage, handling, mixing and application of pesticides), and compare the data with the parameters of 25 nonoccuptionely exposed individuals (control group). Also, the impact of age and duration of occupational exposure for each group of workers was determined. Information about age, medical history, nature of work type and groups of pesticides dealing with, knowledge about pesticides and protection measures used to prevent exposure for each individual were extracted through questionnaired investigation. The obtained data indicated that about 90% of the respondents involved in the different pesticide-related jobs had no interest in knowing the pesticide kind nor the method of protection and safety measures, and 100% of the participants did not use the tasks of prevention during work. Regarding of the hematological and biochemical parameters results showed significant increase in Hb, PCV, MCV, MCH, TLC, Baso., Eos., ALT, AST, AlP, BUN, Creat and UA of industry workers. Also, Hb, MCH, MCHC, ALT, AST, AlP, TP, BUN, create. and UA were significantly increased in mixing and application group. Significant elevations in levels of serum ALT, AST, AlP, BUN, create, and UA were observed for handlers working in storing and transport workers group. A correlation between age/exposure duration in different workers groups (industry, handling and mixing and application worker) and the elevation in vital parameters was established. Industry workers are the most affected by exposure to pesticides than handlers working in mixing and application of pesticides in agriculture and public health. Whereas the least affected group were handlers working in the field of transporting and handling pesticides. Also, data showed a positive correlation between biochemical parameters (ALT, AST, ALP, urea, creatine, uric acid and malondialdehyde) and duration of exposure in the three pesticide occupationally-exposed worker groups. Whereas the relationship between alb., TP, enzymatic activity of AChE and GSH was inverse with increased duration of exposure. Key words: Pesticide exposure, occupation exposure, Industry workers, Pesticide Handlers |