الفهرس 
definition of heart failure…Only 14 pages are availabe for public view
 |  | from | 168 |  |  |
| | | from | 168 | | |
Abstract
Heart failure (HF) is a major health problem because it is
common, and has a high rate of hospitalization and high rate of mortality.
While substantial advances have been achieved in the treatment of heart
failure over the past two decades, HF mortality remains as high as cancer
mortality. Coronary artery disease (CAD) remains the main cause of HF.
The aim of this study. To investigate the association between serum
GDF-15 and chronic HF due to CAD, and its potential usefulness as a
biomarker in these patients.
Methodology This study was conducted on A total of seventy nine
patients at Fayoum University hospitals and was classified as : Fifty
patients having the typical symptoms and signs of heart failure and
diagnosed with either heart failure with reduced ejection fraction (HFrEF)
or heart failure with preserved ejection fraction (HFpEF). Twenty nine
patients as control group. Blood samples for GDF-15 level were
analyzed.
The results demonstrated significant relation between elevated GDF-15
levels and HF patients due to coronary artery disease in comparison to
patients with no HF in the control group. A significant relation between
elevated GDF-15 levels and worse functional status of the patients
represented by NYHA class
Conclusion: Our results suggest that GDF15 could be an independent
marker for diagnosis, and management of patients with heart failure
caused by CAD.