الفهرس | Only 14 pages are availabe for public view |
Abstract Pro-inflammatory cytokines, IL-1β and IL-6, were specifically reported to be involved in the pathophysiology of INS. The chemokine IL- 6 was only recently documented to act as a soluble factor that increases glomerular basement membrane permeability. The aim of this study was to detect the role of IL-6 gene [G572C] polymorphism in the etiology of nephrotic syndrome among the children and the role of polymorphism in response to treatment. The study constitutes 55 children suffering from an INS represent the patients’ group classified into; Ia) Steroid responsive (37 patients), (Ib) Steroid resistant (18 patients), and 50 healthy children represent the control group matched in age and sex with the patients’ group. Our results revealed that IL-6 [G572C] CC genotype and the C allele were significantly more frequent among the patients group than the control group. The IL-6 [G572C] CC genotype was also specifically insignificant difference between steroid-resistant group and the steroidsensitive group. On comparison between patients and controls as regard genotype frequency in the co-dominant model there is a statistically highly significant difference of GC genotype (P <0.01), in the dominant model there is a statistically very highly significant difference (P <0.001) as regard CC+GC genotype and there is also a statistically very highly significant difference between G and C genotypes in the alleles model. On comparison between steroid sensitive and steroid resistant patients as regard genotype frequency, there is a statistically insignificant Summary & Conclusion -- 97 -- difference (P>0.05) as regard the co-dominant model, dominant model, recessive model and alleles. |