الفهرس 
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Abstract
Reinke’s edema is one of the minimal associated pathological lesions (MAPLs) which are observed as diffuse spindle shaped translucent swelling of both vocal folds along their entire length with intact epithelium and causes varying degrees of dysphonia according to its duration, stage and severity.
There are several options for treating Reinke’s edema that ranges from non-surgical conservative procedures which include voice therapy, steroid injection and hyaluronidase injection to the surgical procedures which includes micro- laryngeal phonosurgery, laser surgery using CO2 laser, photoangilotic laser and microdebrider. The aim of this study was to conduct a systematic review to define the different surgical and non-surgical lines of treatment of Reinke’s edema to determine the most effective for managing dysphonia associated with Reinke’s edema.
The current systematic review revealed that surgical lines of treatment are effective over the alternative non-surgical lines. Among the surgical line, the microdebrider proved to be the most effective method particularly for patients with grade II and III Reinke’s edema. More researches with larger sample size
and accurate randomization are needed for further accurate assessment of the effectiveness of cold steel phonosurgery, photoangiolytic KTP Laser, CO2 Laser, combined CO2 Laser and cold steel phonosurgery and hyaluronidase injection taking in consideration the careful assessment of the grade of Reinke’s edema and quality of voice, before and after the treatment measured objectively as well as subjectively.
For patients with grade I Reinke’s edema steroid injection is recommended. Voice therapy is not recommended as sole method for treatment moderate and severe degree of Reinke’s edema; however, it is an important adjunctive for postoperative intervention to maintain appropriate subglottal air pressure. For future research preoperative and postoperative outcome measures results should be mentioned separately to facilitate the comparison between different lines of treatment and GRBAS scale and video-laryngostroboscopic examination should be included in all future articles.